Apollo 13 is Sativa dominant and is known for providing a psychedelic and spacey head high. First and foremost, users report a rise in creativity, followed by uplifted mood and feelings of euphoria. Like other Sativa strains, this one is also known to give users energy. One of the most interesting benefits of this strain, that is contrary to cannabis reputation, is the increase in focus it induces. An increase in prescription volume for adults with ADD has been reported in some states on the West Coast. This strain also produces some of the common negative side effects, including dry mouth and eyes, anxiety, headaches and paranoia.

As other Sativas, Apollo 13 is best used early in the day and is recommended for people living  with stress, anxiety and depression. Although not helpful in treatment of severe pain, the strain has been used by some people to relieve minor aches. Apollo 13 can also be used to relieve nausea and induce appetite.

Apollo 13's genetics were designed by the Brothers Grimm as a cross between Genius and Princess 75. This strain is especially recommended for beginner growers because it requires little attention. After flowering seven to eight weeks, Apollo 13 will produce a heavy yield. It is ideal for an indoor Sea of Green setup, but in the proper climate can also be grown outdoors. Other breeders have also released their own versions of Apollo 13.