Island Sweet Skunk, also known as ISS or Sweet Island Skunk, has been cultivated on Vancouver Island in British Columbia, Canada, for decades. Nirvana's version of this strain made the High Times Top 10 Canadian Strains of All Time list in 2013.

First bred by Federation Seeds, this hybrid should not be confused with Sweet Skunk from Spice of Life. This strain is heavily influenced by Skunk #1 as well as a 1970's California Skunk called Sweet Skunk. A Vietnam veteran brought Sweet Skunk to Federation Seeds, where it was crossed with an unknown Sativa. Smelling and tasting like sweet citrus with a bit of skunk, Island Sweet Skunk is a strain that starts with a perky upbeat high, quickly followed by a soft body buzz.

This hybrid can have as much as 19% THC and may be effective daytime medication for minor aches, arthritis, nausea, and appetite loss. Island Sweet Skunk can encourage a good mood and can be used to treat depression, anxiety, and stress. Users often feel focused and creative. It may also help with migraines, fatigue, and nerve pain.

Island Sweet Skunk is easier to grow than many other Sativa-heavy strains. It grows well in the Screen of Green setup. It can do well inside, but because of its height and the space it requires, the strain may do better outdoors or in a greenhouse. During the eight to nine week flowering period, plants will need to be supported. Growers may harvest yields of over 200 grams. Outside, this strain usually finishes in mid-October.