The Best Strains of All Time: According to Wikileaf Users

How many have you tried?

Looking for the best cannabis strain can feel like an exciting (or overwhelming) adventure. We’ve collected thousands of reviews from our users over the years to help you research your options. Keep reading to find out how they rank the 10 best weed strains of all time! 

10. Durban Poison

Closing the rankings in 10th place is Durban Poison, a classic landrace strain known for producing a high so strong, some call it psychedelic. If you find this strain on the shelves of your local cannabis retail store, you’ve run into an original sativa with South African roots. 

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  • THC Average: 26%
  • CBD Average: <1%
  • Dominant Terpene: Terpinolene  

Durban Poison is not for the novice. As one reviewer said, “It’s like a roller coaster you can’t exit […] It’s a wake and bake delight for the experienced user.” 

9. Jack Herer

Most likely bred from Haze, Northern Lights #5, and Shiva Skunk, Jack Herer is a beloved sativa strain known for producing an energizing, inspiring effect. The strain gets its name from cannabis activist and author of the seminal cannabis book, The Emperor Wears No Clothes

  • THC Average: 24%
  • CBD Average: <1%
  • Dominant Terpene: Terpinolene 

Despite its high THC and low CBD content, Jack Herer’s energizing effects aren’t typically overwhelming. Here’s what one reviewer said: 

“Jack Herer is hands down the best strain I’ve ever smoked […] I feel endlessly creative, calm, completely aware. My anxiety vanishes and I can actually breathe. A truly beautiful strain.” 

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8. Skywalker OG

If you’re looking for a wake and bake, Skywalker OG is NOT it. Known for producing a sedating body high, this indica is a staple for chronic pain patients and those who struggle with insomnia or anxiety. 

  • THC Average: 26%
  • CBD Average: <1%
  • Dominant Terpene: Pinene 

This is how one user reviewed Skywalker OG’s effect:

“Best high I’ve ever had. the high is so intense and CLEAN the next morning you wake up feeling refreshed. Really recommend for people who suffers from anxiety or stress.” 

7. Girl Scout Cookies

No top weed strain list would be complete without including the legendary Girl Scout Cookies. An indica frequently used at night, GSC gained notoriety for its intense effects thanks to Berner, cannabis entrepreneur and hip-hop artist.  

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  • THC Average: 28%
  • CBD Average: 1%
  • Dominant Terpene: Caryophyllene

Newcomers to cannabis, take heed of this reviewer’s advice:

“When this strain first hit, some years back, it blew my mind. […] To this day, I’m happy to find some. It’s best used in minute amounts for low tolerance or inexperienced users, though a great ride for someone willing to commit to possibly tripping out a little.”

6. Gorilla Glue

Gorilla Glue is one of the most potent strains around, just as sticky-icky with trichomes as its name implies. Because of its powerful medicinal effects, Gorilla Glue is used to tackle some of the most frustrating conditions: migraines, insomnia, and depression. 

  • THC Average: 28%
  • CBD Average: <1%
  • Dominant Terpene: Caryophyllene 

As this reviewer describes, Gorilla Glue offers users the best of everything cannabis has to offer:

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“This strain is my go-to. I love the fact that it makes me laugh for the first hour or so, then the body high hits and the giggles are still there which is awesome. I have a racing mind, and it takes that away allowing me to fall asleep.” 

5. Hindu Kush

The only other landrace on this list, Hindu Kush is an indica strain with ancient genetics. The strain is named after the Hindu Kush Mountain range, one of the locations believed to be cannabis’ origins. 

  • THC Average: 20%
  • CBD Average: <1%
  • Dominant Terpene: Limonene 

According to this user, Hindu Kush is best used at night in a safe location:

“I find this indica plant’s best for nighttime because […] it does have very much sedating effects. This is one of my favorite strains because it really helps relieve stress and has good pain relief properties.” 

4. Gorilla Glue #4

If the THC average below doesn’t make you gulp, you’re either a regular cannabis veteran or brand new. Shockingly, Gorilla Glue #4 is even more potent than its popular predecessor listed above. 

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  • THC Average: 32%
  • CBD Average: <1%
  • Dominant Terpene: Myrcene 

While recreational users might love GG4 for its THC content, it can be just as life-giving for medical marijuana patients. Here’s what one user said:

“This strain (and it’s children) gave me my life back and makes me feel like a normal person. […] I have several severe autoimmune diseases as well as epilepsy, narcolepsy, and GAD. If I smoke this before bed, I can get out of bed in the morning without hobbling to the bathroom. The anti-inflammatory properties of this strain must be off the charts.” 

3. Sour Diesel

The pungent flavor inspiring Sour Diesel’s name likely comes from its concentration of caryophyllene, the dominant terpene in black pepper, oregano, and thyme. A strain known for its creative, uplifting, and energizing effect, sour diesel is commonly used to manage depression and anxiety. 

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  • THC Average: 26%
  • CBD Average: 2%
  • Dominant Terpene: Caryophyllene 

Look at what this reviewer says about Sour Diesel’s mood amplifying effects:

“She’s very positive, very chill, just the right amount of energetic mood elevating, and effective for depression. Also good for anxiety and a top sativa in my book.” 

2. Blue Dream

Second only to Green Crack, Blue Dream is one of our users’ most favorite cannabis strains of all time. One of the only strains with enough CBD to be mentioned, Blue Dream is particularly well known in the medical marijuana community. It’s commonly used to treat depression, anxiety, and a loss of appetite. 

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  • THC Average: 27%
  • CBD Average: 2%
  • Dominant Terpene: Myrcene 

One reviewer said this about Blue Dream’s effects:

“I’m more of an Indica smoker. But Blue Dream is my GO-TO for anxiety. I can’t recommend this one enough if you have bad anxiety. This is in my top 5 favorite strains of all time.”

1. Green Crack

Green Crack (as dubbed by Snoop Dog) ranks as the number one most popular cannabis strain available among Wikileaf users. Green Crack is known for producing an energizing high, not the kind of overwhelming effect you’d expect given its hyperbolic name. 

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  • THC Average: 24%
  • CBD Average: <1%
  • Dominant Terpene: Myrcene 

One medical marijuana user described Green Crack’s effect this way:

“Green Crack […] helps with my Rheumatoid Arthritis, and it gives me the energy to get up and complete my workday. It even allows for enough energy to do something after work too!”

What’s the Best Weed Strain for You? 

Consider the following factors as you explore different weed strains:

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  • Symptoms of your medical condition – Whether it’s inflammation, pain, nausea, spasticity, seizures, or negative mood, chances are there’s a strain with the right combination of compounds to provide relief. 
  • Expert advice – We’re not medical experts, so we encourage you to go to your bona fide healthcare practitioner before incorporating cannabis into your wellness routine.
  • Cannabinoid content – THC is the most well-known cannabinoid, but it’s only one of approximately 100 cannabinoids loaded with therapeutic potential housed in the cannabis plant.   
  • Terpenes – Cannabinoids get most of the attention, but terpenes have important (and often therapeutic) effects on the way your body responds to weed. 

There are thousands of cannabis strains available. Always talk to your doctors, pay attention to the research, and check out our database of cannabis strains to explore what weed has to offer. 

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