Karamelo, a pure Indica strain, is a mixture of strains from Kannabia Seeds. It is designed to be vigorous with a short flowering period. Karamelo is a smorgasbord of different landrace Indicas, instilling a high typical of its Indica heritage. It produces calming waves, relaxing muscles and imparting positive feelings. Its THC content may reach 20%, and it is described as tasting like sweet caramel.

This strain should be used later in the afternoon and evening for relaxation, making it helpful in relieving anxiety and stress. Karamelo may also be used to ease chronic aches and pains as well as insomnia. For some, it may also stimulate appetite.

Its Indica structure (short and wide plants rather than tall and thin) makes this strain most suitable for indoor cultivation. Karamelo has a short flowering period, typically lasting between 50 and 55 days. When grown outdoors, the strain is usually ready for harvest in mid to late September. Fertilizers should be used with great caution, since the plant grows continuously. It should not be germinated for less than 15 days, and EC levels should not go over 1.4 (though in a hydroponics setup, levels of up to 1.6 are acceptable). Indoor growers can expect 300 grams per square meter in a good harvest, while outdoor growers may get up to 400 grams per plant.