Named after a crass, over the top, supremely confident alien-killing videogame character, the Duke Nukem (DN) strain was created by Cabin Fever Seed Breeders. It was bred by crossing one of their male Chemmando plants with a female Chernobyl from TGA Subcool Seeds. The strain's lineage includes several well-known strains: Mendo Purps, Trainwreck, and Jack the Ripper to name a few. DN's cerebral effects may induce creativity, happiness, and a fit of the giggles.

Suitable for daytime use, this mostly Sativa strain is effective for easing headaches and migraines. It can stabilize mood and help manage stress and anxiety. It can also stimulate appetite and help people with chronic fatigue to feel more energized.

DN can grow easily either indoors or out. It is suitable for all growers, regardless of experience. It has two particular phenotypes. The more Chemmando-like phenotype will stay shorter, but stretch about 50% of its size when flowering. The Chernobyl-like phenotype will stretch to about 75% of its original height when flowering. Flowering finishes in nine to eleven weeks.